文章基本信息

标题：A Preclinical Evaluation on Antioxidant and Gastroprotective Effect of Dioscorea Bulbifera in Wistar Rats
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作者：J. Balasubramanian ; R. Dhanalakshmi ; P. Jibnomen 等
期刊名称：Indian Journal of Innovations and Developments
印刷版ISSN：2277-5382
电子版ISSN：2277-5390
出版年度：2012
卷号：1
期号：3
页码：149-154
出版社：Indian Society for Education and Environment
摘要：The present study was undertaken to evaluate the gastro-protective effect of hydro alcohol extract of Dioscorea bulbifera (DB) tubers Linn in indomethacin-induced gastric ulcers in rats at doses of 100, 200 and 400 mg/kg body weight. The gastric lesions were significantly reduced by all doses of DB as compared with the Indomethacin (100 mg/kg body weight) treated group. In the stomach tissues of treated animals, the in-vitro antioxidant levels were evaluated. The administration of indomethacin caused a significant decrease in the levels of peroxidase, catalase (CAT) and an increase in glutathione peroxidase (GPx) and reduced glutathione (GSH), and lipid peroxidation (LPO) level. The administration of all doses of DB reversed the trend, inducing a significant increase of peroxidase, Catalase and a reduction in GPx, GSH and LPO level in tissues. These results suggest that the gastro-protective effect of DB can be attributed to its reducing effect on the oxidative damage in rats.
关键词：Gastro-protective Activity, Dioscorea Bulbifera, Indomethacin, Antioxidant Activity