文章基本信息

标题：Characterization and Synthesis of Some α, β-unsaturated Ester Derivatives from Aliphatic Aldehydes
其他标题：Characterization and Synthesis of Some α, β-unsaturated Ester Derivatives from Aliphatic Aldehydes
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作者：M. A. Bari ; M.M. Karim ; M. M. Hoque 等
期刊名称：Journal of Scientific Research
印刷版ISSN：2070-0237
电子版ISSN：2070-0245
出版年度：2010
卷号：2
期号：2
页码：343-350
DOI：10.3329/jsr.v2i2.4167
语种：English
出版社：Rajshahi University
摘要：Ethyl diazoacetate compound is useful synthetic intermediates for α, β-unsaturated ester in organic synthesis but, due to its toxicity and unpredictable explosive behaviour, its unique reactivity has not been fully exploited and the use on large scale has been avoided. We have developed a reliable method that generates EDA compound in situ. Our approach is based on the Wittig reaction, which utilizes EDA as diazo precursors. In the presence of Cu(OTf)2, we found that diazo compounds can be cleanly converted to alkenyl compounds under mild reaction conditions and in a narrow range of solvents. These diazo compounds can then be induced to react directly with aldehydes to synthesize olefin. We have shown the usefulness of this chemistry in a number of different transformations, such as Wittig olefination reactions chemistry as applied toward the synthesis of more complicated molecules. Keywords: α, β-unsaturated ester; Acryclic acid ethyl ester; Aliphatic aldehyde; Cu(II) triflate; Triphenylphosphine. © 2010 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. DOI: 10.3329/jsr.v2i2.4167 J. Sci. Res. 2 (2), 343-350 (2010)
关键词：Chemistry;Unsaturated ester; Acryclic acid ethyl ester; Aliphatic aldehyde; Cu(II) triflate; Triphenylphosphine.