文章基本信息

标题：Microwave-assisted Efficient Synthesis of Isatins and spiro -Thiadiazolines under Green Chemistry Protocol
其他标题：Microwave-assisted Efficient Synthesis of Isatins and spiro-Thiadiazolines under Green Chemistry Protocol
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作者：M. M. Hossain ; M. A. Foysal ; M. Mahabub 等
期刊名称：Journal of Scientific Research
印刷版ISSN：2070-0237
电子版ISSN：2070-0245
出版年度：2010
卷号：2
期号：2
页码：322-329
DOI：10.3329/jsr.v2i2.3731
语种：English
出版社：Rajshahi University
摘要：MW-assisted treatment of oximinoacetanilides obtained from substituted primary aromatic amines was carried out in conc. H2SO4 medium for 5-10 sec to give cyclic amides (isatins) through intramolecular cyclization by means of electrophilic aromatic substitution. Isatins reacted with thiosemicarbazide under MW-condition gave the corresponding Schiff-bases. The Schiff-bases undergo cyclization in presence of minimal Ac2O under MW-irradiation for 3-4 min to give the spiro-thiadiazoline acetyl derivatives in excellent yield. Keywords: Microwave-synthesis; Isatins; Schiff-base; spiro-Thiadiazoline; Green chemistry. © 2010 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. DOI: 10.3329/jsr.v2i2.3731 J. Sci. Res. 2 (2), 322-329 (2010)
关键词：Chemistry;Microwave-synthesis; Isatins; Schiff-base; spiro-Thiadiazoline; Green chemistry.