首页    期刊浏览 2024年12月12日 星期四
登录注册

文章基本信息

  • 标题:Immune cell screening of a nanoparticle library improves atherosclerosis therapy
  • 作者:Jun Tang ; Samantha Baxter ; Arjun Menon
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2016
  • 卷号:113
  • 期号:44
  • 页码:E6731-E6740
  • DOI:10.1073/pnas.1609629113
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Immunological complexity in atherosclerosis warrants targeted treatment of specific inflammatory cells that aggravate the disease. With the initiation of large phase III trials investigating immunomodulatory drugs for atherosclerosis, cardiovascular disease treatment enters a new era. We here propose a radically different approach: implementing and evaluating in vivo a combinatorial library of nanoparticles with distinct physiochemical properties and differential immune cell specificities. The library’s nanoparticles are based on endogenous high-density lipoprotein, which can preferentially deliver therapeutic compounds to pathological macrophages in atherosclerosis. Using the apolipoprotein E-deficient (Apoe−/−) mouse model of atherosclerosis, we quantitatively evaluated the library’s immune cell specificity by combining immunological techniques and in vivo positron emission tomography imaging. Based on this screen, we formulated a liver X receptor agonist (GW3965) and abolished its liver toxicity while still preserving its therapeutic function. Screening the immune cell specificity of nanoparticles can be used to develop tailored therapies for atherosclerosis and other inflammatory diseases.
  • 关键词:nanomedicine ; drug delivery ; immunotherapy ; molecular imaging ; atherosclerosis
Loading...
联系我们|关于我们|网站声明
国家哲学社会科学文献中心版权所有