文章基本信息

标题：Refined Agent Model Using Shape-Based Grained Structure: Application to Membrane Molecules
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作者：François Vallée ; Marie Beurton-Aimar ; Hien T. Tran 等
期刊名称：Journal of Computer and Communications
印刷版ISSN：2327-5219
电子版ISSN：2327-5227
出版年度：2016
卷号：04
期号：13
页码：12-22
DOI：10.4236/jcc.2016.413002
语种：English
出版社：Scientific Research Publishing
摘要：Multi-agent model is well-known to suit design of complex systems. This paradigm allows describing autonomous entities to interact together directly or through their environment. It is specially adapted to design 3D simulations taking into account spatial constraints on agents. In this work, we have designed a multi-agent model which adds a feature to the classical representation of agent: a body, encapsulating a physical model of the agent. We have applied this model to lipids and proteins belonging to the inner mitochondrial membrane, a biological membrane. Information provided by atomic structures is available through international databases and has been used to design a shape-based grain model for the agent body. We selected a model with three grains per molecule in which each grain is characterized by a type determining how they interact together and consequently the agent behaviors. Lipids and two kinds of protein structures have been described within this model allowing us to simulate their organization in membranes.
关键词：Biological Simulations;3D Reactive Agent;Sub-Cellular Level;Molecule Interactions