文章基本信息

标题：Checkpoint recovery in cells: how a molecular understanding can help in the fight against cancer
本地全文：下载
作者：René H. Medema ; Libor Macurek
期刊名称：F1000 Biology Reports
电子版ISSN：2051-7599
出版年度：2010
卷号：3
DOI：10.3410/B3-10
语种：English
出版社：Faculty of 1000 Ltd
摘要：Dysregulation of the cell cycle is the underlying mechanism of neoplasia. Healthy cells prevent propagation of DNA mutations to progeny by activation of cellular checkpoints, which allows time for DNA repair. On the other hand, activation of the DNA damage response is also the general principle of many current cancer treatments. Thus, recent advances in understanding how checkpoints in the cell cycle work at the molecular level open the door to new approaches to antitumor therapy.