文章基本信息

标题：Mitochondria and apoptosis: a quick take on a long view
本地全文：下载
作者：Melissa J Parsons ; Douglas R Green
期刊名称：F1000 Biology Reports
电子版ISSN：2051-7599
出版年度：2009
卷号：1
DOI：10.3410/B1-17
语种：English
出版社：Faculty of 1000 Ltd
摘要：Fifteen years of apoptosis research have led to the widely accepted idea that the major form of programmed cell death in mammals proceeds via the mitochondria, and that mitochondrial control of apoptosis is regulated by a specialized family of proteins known as the Bcl-2 family. Here we will consider some very recent data that has shed new insight into the regulation of these proteins and the impact of mitochondrial dynamics on mitochondrial outer membrane permeabilization (MOMP) and apoptosis.