文章基本信息

标题：The search for novel analgesics: targets and mechanisms
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作者：Tony L. Yaksh ; Sarah A. Woller ; Roshni Ramachandran 等
期刊名称：F1000 Biology Reports
电子版ISSN：2051-7599
出版年度：2015
卷号：7
DOI：10.12703/P7-56
语种：English
出版社：Faculty of 1000 Ltd
摘要：The management of the pain state is of great therapeutic relevance to virtually every medical specialty. Failure to manage its expression has deleterious consequence to the well-being of the organism. An understanding of the complex biology of the mechanisms underlying the processing of nociceptive information provides an important pathway towards development of novel and robust therapeutics. Importantly, preclinical models have been of considerable use in determining the linkage between mechanism and the associated behaviorally defined pain state. This review seeks to provide an overview of current thinking targeting pain biology, the use of preclinical models and the development of novel pain therapeutics. Issues pertinent to the strengths and weaknesses of current development strategies for analgesics are considered.