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标题：Recent advances in understanding and managing leiomyosarcomas
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作者：Florence Duffaud ; Isabelle Ray-Coquard ; Sébastien Salas 等
期刊名称：F1000 Biology Reports
电子版ISSN：2051-7599
出版年度：2015
卷号：7
DOI：10.12703/P7-55
语种：English
出版社：Faculty of 1000 Ltd
摘要：Leiomyosarcomas are malignant mesenchymal tumours that derive from the smooth muscle lineage. They are studied and frequently treated as if they are the same as other soft tissue sarcomas. Recent developments suggest that a different approach may be more appropriate. Their underlying genetic mechanisms remain unclear, and complex. Unbalanced karyotypic defects are the only shared features observed across different leiomyosarcoma subtypes. Unlike other soft tissue sarcomas, leiomyosarcomas are particularly sensitive to the combination of gemcitabine and docetaxel. Furthermore, treatment with trabectedin has shown a good efficacy in leiomyosarcomas, mainly in the form of chronic disease stabilisation.