文章基本信息

标题：Recognition of Watson-Crick base pairs: constraints and limits due to geometric selection and tautomerism
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作者：Eric Westhof ; Marat Yusupov ; Gulnara Yusupova 等
期刊名称：F1000 Biology Reports
电子版ISSN：2051-7599
出版年度：2014
卷号：6
DOI：10.12703/P6-19
语种：English
出版社：Faculty of 1000 Ltd
摘要：The natural bases of nucleic acids have a strong preference for one tautomer form, guaranteeing fidelity in their hydrogen bonding potential. However, base pairs observed in recent crystal structures of polymerases and ribosomes are best explained by an alternative base tautomer, leading to the formation of base pairs with Watson-Crick-like geometries. These observations set limits to geometric selection in molecular recognition of complementary Watson-Crick pairs for fidelity in replication and translation processes.