文章基本信息

标题：Cytokines in chronic respiratory diseases
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作者：Sergei P. Atamas ; Svetlana P. Chapoval ; Achsah D. Keegan 等
期刊名称：F1000 Biology Reports
电子版ISSN：2051-7599
出版年度：2013
卷号：5
DOI：10.3410/B5-3
语种：English
出版社：Faculty of 1000 Ltd
摘要：Cytokines are small, secreted proteins that control immune responses. Within the lung, they can control host responses to injuries or infection, resulting in clearance of the insult, repair of lung tissue, and return to homeostasis. Problems can arise when this response is over exuberant and/or cytokine production becomes dysregulated. In such cases, chronic and repeated inflammatory reactions and cytokine production can be established, leading to airway remodeling and fibrosis with unintended, maladaptive consequences. In this report, we describe the cytokines and molecular mechanisms behind the pathology observed in three major chronic diseases of the lung: asthma, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis. Overlapping mechanisms are presented as potential sites for therapeutic intervention.