文章基本信息

标题：Membrane deformation and separation
本地全文：下载
作者：Rainer Beck ; Britta Bruegger ; Felix T Wieland 等
期刊名称：F1000 Biology Reports
电子版ISSN：2051-7599
出版年度：2010
卷号：2
DOI：10.3410/B2-35
语种：English
出版社：Faculty of 1000 Ltd
摘要：Biological membranes are highly dynamic (e.g., during cell division, organelle biosynthesis, vesicular transport, and neurotransmitter release). They can be shaped into protein-coated transport vesicles or tubules and undergo regulated fusion. The life of transport vesicles depends on highly specific and tightly regulated protein machineries, which not only shape the donor membrane into nascent budding structures but also help to overcome the energy barrier to break the bilayers apart in order to pinch off nascent vesicles. Ultimately, vesicular membranes have to fuse with a target lipid bilayer, a process that again requires remodeling. Here, we highlight recent insights into mechanisms that lead to membrane deformation in the process of vesicular budding.