文章基本信息

标题：Recent imaging advances in the diagnosis and management of Parkinson’s disease
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作者：David J Brooks ; Nicola Pavese
期刊名称：F1000 Biology Reports
电子版ISSN：2051-7599
出版年度：2009
卷号：1
DOI：10.3410/M1-82
语种：English
出版社：Faculty of 1000 Ltd
摘要：In this review we report novel sensitive imaging biomarkers for Parkinson’s disease (PD) and its atypical variants. Diffusion tensor imaging and transcranial brain sonography are potentially promising techniques that can differentiate typical PD from atypical variants (multiple system atrophy and progressive supranuclear palsy) and from benign tremor disorders. Non-motor symptoms, such as dementia, depression, and sleep disruption, are often more distressing to PD patients than their slowness and stiffness. Dopamine replacement treatment can also lead to complications such as dyskinesias, impulse control disorders, and psychosis. Recent positron emission tomography studies have helped to clarify the physiopathological mechanisms underlying dementia and compulsive gambling in PD and provide a rationale for therapeutic strategies.