文章基本信息

标题：Reaching a consensus on the mechanism of dynamin?
本地全文：下载
作者：Aurélien Roux
期刊名称：F1000 Biology Reports
电子版ISSN：2051-7599
出版年度：2014
卷号：6
DOI：10.12703/P6-86
语种：English
出版社：Faculty of 1000 Ltd
摘要：Among the proteins involved in lipid membrane remodeling in intracellular traffic, dynamin has been the focus of many studies, as it was the first protein shown to be mechanistically involved in membrane fission: the reaction by which a vesicle neck can be severed to release a free vesicle. After almost 25 years of research, a wide variety of data from various techniques has been acquired on the mechanism by which dynamin breaks membranes. However, the literature may sometimes sound confusing, and the primary goal of this review will be to provide a stepping stone towards a potential consensus on how dynamin may work. I will then discuss the most recent findings in light of previous work, and the future possible lines of research in the field of dynamin.