文章基本信息

标题：Synthesis and Evaluation of p -Aminobenzoylhydroxypropyl Cellulose
本地全文：下载
作者：Kashif-ur-Rehman Khan ; Chitchamai Ovatlarnporn
期刊名称：Pakistan Journal of Nutrition
印刷版ISSN：1680-5194
电子版ISSN：1994-7984
出版年度：2016
卷号：15
期号：8
页码：725-728
DOI：10.3923/pjn.2016.725.728
出版社：Asian Network for Scientific Information
摘要：Hydroxypropyl cellulose (HPC) was selected as a macromolecular carrier for the attachment of para-aminobenzoic acid (PABA) for different pharmaceutical, biomedical and nutritional applications. HPC-PABA ester conjugate was synthesized in a two easy steps that were performed homogeneously. In the first step, the primary amino group of PABA was protected by 98% formic acid and during the second step the protected PABA was coupled with the HPC polymer in DMF by using 4-(dimethylamino)pyridine as a base and N -(3-dimethylaminopropyl)- N -ethylcarbodiimide hydrochloride (EDC.HCl) as a coupling reagent at room temperature. The optimum conditions for deprotection process were also determined. Novel macromolecular conjugate has solubility in both water and organic solvents. HPC-PABA ester conjugate was synthesized with good percentage yield and purity and well identified by FT-IR and ¹H-NMR techniques. According to this new synthesis plan HPC-PABA conjugate can be prepared easily and has potential for pharmaceutical, textile and biomedical sectors.