文章基本信息

标题：Optimal two-stage sequential robust design for gene-intervention studies
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作者：Zhaohai Li ; Aiyi Liu ; Lihan K. Yan 等
期刊名称：Statistics and Its Interface
印刷版ISSN：1938-7989
电子版ISSN：1938-7997
出版年度：2011
卷号：4
期号：4
页码：431-441
DOI：10.4310/SII.2011.v4.n4.a2
出版社：International Press
摘要：Gene-intervention studies investigate the responsiveness to therapies according to individuals’ genetic profiles. We propose a two-stage sequential design for these studies and investigate the cost of the sample size versus the statistical power. In a typical sequential design, a single normally distributed test statistic is used. For a genetic study, the robust test is used because of the uncertainty of the underlying genetic model (e.g. the recessive, additive or dominant models). The robust test statistic that we consider in the twostage sequential design is the maximum of three correlated normally distributed statistics, each which is optimal under the corresponding genetic model. We study various factors that affect minimizing the average sample number (ASN) or maximizing the power of a gene-intervention study under the two-stage sequential design and make recommendations for the optimal solutions under different scenarios.
关键词：optimal two-stage design; MAX; group sequential; gene-intervention