This is taecase report of a 64 year old male patient with the chief complaint of esophagial vahix bjeeding, who has been scheduled for emergency sever hypoalbuminemia, and abnormal liver function test. Anesthesia was induced with nitrous oxide, Innovar, morphine sulfate, pancuronium bromide and Valium. The long operation of 3 hours required transfusions of 5 pints banked bloods without any and difficulty. Anesthesia was reversed with Nsrcan, neostigmain and Atropine. In the recovery room, the patient's ventilation was satisfactory but he did not recover from deep coma until 5 hours after surgery. After repeated injection of Narcan intramuscularly the patient awoke from his deep asleep at midnight without any delayed sequelae.