文章基本信息

标题：MICROBIAL L-ASPARAGINASE: PRESENT AND FUTURE PROSPECTIVE
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作者：Rati Sinha ; H R Singh ; S K Jha 等
期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2013
卷号：2
期号：11
页码：7031
出版社：S&S Publications
摘要：L-Asparaginase is a well known enzyme for its chemotherapeutic properties since it catalyzes hydrolysis of the amino acid asparagine into aspartate and ammonia which is essential for tumour cells. It has been effectively used in the treatment of acute lymp hoblastic leukemia and lymphosarcoma from decades. This article comprises a brief introduction about the enzyme, its sources, mechanism of action as well as a detailed information about its production and purification.This article also provide some recent updated information about its structure, physiochemical and kinetic properties of the enzyme as well as about modifications such as cloning to get the enzyme in recombinant form, formulation and immobilization of the enzyme.
关键词：Asparaginase; chemotherapeutic; physiochemical; kinetic; immobilization