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标题：Spectroscopic and Characterization of Medical and Physical Applications of Metal Complexes of Schiff bases in nano-sized Shape: Mg(II), Ca(II) and Ba(II) Schiff base Complexes
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作者：Omar B. Ibrahim ; Mahmoud A. Mohamed ; Moamen S. Refat 等
期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2013
卷号：2
期号：11
页码：6355
出版社：S&S Publications
摘要：Mg(II), Ca(II) and Ba(II) metal chelates with formulas, [Mg(HL)2(Cl)2].6H2O, [Ca(HL)2(Cl)2].2H2O and [Ba(HL)2(H2O)2].Cl2.2H2O thatHL is the Schiff base moiety formed from condensation of 2-thiophenecarboxaldehyde with 2-chlorophenyl hydrazine have been prepared and characterized by elemental analysis and spectroscopic measurements (infrared and 1H-NMR). Elemental analysis of the complexes suggests the stoichiometry is 1:2 (metalligand). Infrared spectra of the complexes agree with the coordination to the central metal atom through the nitrogen of the 2-chlorophenyl hydrazine(–Ph–NH-) group and the sulfur atom of the thiophene ring. Biological properties of prepared compounds were studied included antimicrobial activity and cytotoxicity. A potent antimicrobial activity evaluated by disc inhibition zone and variety degree of activity recorded against gram-positive; gram-negative and fungal strains. Cytotoxicity against two cell lines; MCF-7 and HePG-2 were evaluated and IC50 values were calculated. The [Ba(HL)2(H2O)2].Cl2.2H2O and [Mg(HL)2(Cl)2].6H2O had the highest antitumor effect with IC50 values; 32.6 and 30.4μg/ml for MCF-7 cell line and 37.5 ; 39.5 μg/ml for HePG-2 cell line.
关键词：Spectroscopic; alkaline earth metal complexes; Schiff base