文章基本信息

标题：Controlled Inversion of 4'chiral Centre in Protected Carbasugar from D-Ribose
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作者：Bitla Sampath ; Kammari Bal Raju ; Atcha Krishnam Raju 等
期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2016
卷号：5
期号：6
页码：10625
DOI：10.15680/IJIRSET.2015.0506203
出版社：S&S Publications
摘要：The synthesis of 2,2-dimethyl-6-(trityloxymethyl)tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol wasstarted from D-Ribose. The important ring closure step was carried out by Grubbs catalyst to form pentene carbasugarwhere is cyclopentene will be a central ring. Catalytic hydrogenation of the c=c has yielded the D-Ribose configuredsaturated carbasugar with excellent diastereomeric ratio (~98%). The inversion of the selective chiral center was doneand the molecule 9 can be a new class of key intermediate for the synthesis of novel series of nucleoside analogs
关键词：Stereo specific Hydrogenation D-Ribose Carabasugar; Steric hindrance; carbocyclic nucleoside;analogs; D-ribose configuration