文章基本信息

标题：Hematopoietic stem cell transplantation in children: current practice
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作者：S. Giardino ; L.E. Radu ; G. Dini 等
期刊名称：Drugs and Cell Therapies in Hematology
印刷版ISSN：2281-4876
出版年度：2013
卷号：1
期号：1
页码：43-58
出版社：PAGEPress Publications
摘要：Over the years, indications to hematopoietic stem cell transplantation (HSCT) have in- creased thanks to the progress in techniques and to the results that have been ob- tained. Several malignant and non-malignant diseases of childhood represent a model of how progress in HSCT has modified the natural course and the poor prognosis of many of these diseases. In addition, increased knowledge of the biological mechanisms in- volved in engraftment, in graft-versus-tumor effect and in graft-versus-host disease, and the new techniques that have been developed to control them have improved the efficacy and safety of HSCT. By reviewing currently available data and published expe- rience, this paper describes the current practice in the application of HSCT in children and defines the indications to autologous and allogeneic HSCT, donor selection criteria and various potential sources of stem cells.
关键词：stem cells transplantation; ; childhood; malignancies; alternative ; donor; haploidentical; cord blood