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标题：Kandungan Kimia dan Uji Antiinflamasi Ekstrak Etanol Lantana camara pada Tikus Putih (Rattus norvegicus) Jantan
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作者：NUR ANNIS HIDAYATI ; SHANTI LISTYAWATI ; AHMAD DWI SETYAWAN 等
期刊名称：Bioteknologi
印刷版ISSN：0216-6887
出版年度：2008
卷号：5
期号：1
页码：10-17
DOI：10.13057/biotek/c050102
出版社：UNS Solo
摘要：Lantana camara L. is a widely distributed plant on tropics region belongingto the Family Verbenaceae. In Indonesia, the plant is used in traditionalmedicines of edema and rheumatisms. The aims of this research were tocompare saponins, flavonoids, and essential oils constituents among theroots, the leaves, and the fruits and to know about anti-inflammatoryeffects of ethanolic extracts of L. camara on white male rats. The frameworkof the research was that the saponins, flavonoids, and essential oilsconstituents of L. camara have an anti-inflammatory effect. Organs with thehighest constituents of saponins, flavonoids and essential oils would expectgiving optimal anti-inflammatory effects. Complete Randomized Designwith five treatment groups, each of the treatment had five repetitions, wasused in this study. Each group have been treated: Group I CMC 0.5%control (placebo), Group II positive control (Na-diclofenac), Group III, IVand V giving ethanolic extracts of L. camara dose 720, 1080 and 1440 mg/kgBW, respectively. The inflammation was produced by sub plantar injectionof carrageenan suspension in the right hind paw of the rats. Thequantitative data of Area under Curve of edema percentage were analyzedstatistically with SPSS program using One-Way ANOVA followed by LSDtest. The results showed that the highest constituents of saponins,flavonoids, and essential oils were found in the leaves. Ethanolic extracts ofL. camara’s leaves dose 720 mg/kg BW had given the highest antiinflammatoryeffects (38.1%).
关键词：Lantana camara L.; saponins; flavonoids; essential oils; antiinflammatory