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标题：Pengaruh Pemberian Ekstrak Daun Sambiloto ( Andrographis paniculata ) terhadap Struktur Mikroanatomi Hepar dan Kadar Glutamat Piruvat Transaminase Serum Mencit ( Mus musculus ) yang Terpapar Diazinon
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作者：TRI WULANDARI ; MARTI HARINI ; SHANTI LISTYAWATI 等
期刊名称：Bioteknologi
印刷版ISSN：0216-6887
出版年度：2007
卷号：4
期号：2
页码：53-58
DOI：10.13057/biotek/c040204
出版社：UNS Solo
摘要：Diazinon is a pesticide which is often using by farmer to kill insect as theenemy of the plant. The over using of pesticide may result in the remainingof diazinon residue in farming product. This residue can cause the damageof body tissue, especially liver. The aim of research were to find out theeffect of leaves sambiloto (Andrographis paniculata Ness.) extract onmicroanatomic structure of liver and serum glutamate pyruvatetransaminase (GPT) level of mice (Mus musculus L.) exposed to diazinon.The research used Compelete Random Design with five treatments. Thetreatment of each group were using CMC 1% (placebo control), diazinonsolution 40 mg/Kg BW (negative ontrol) and the leaves sambiloto extract12,6; 25,2 and 37,8 mg /kg BW. Diazinon solution was given within 10 daysand continued with extract of sambiloto leaves also within 10 days.Parameter observed was the microanatomic structure of liver and serumGPT level. The data was analyzed of Analysis of Varians (Anova) andcontinued with DMRT at significance 5%. The result of the researchshowed that the giving of the extract of sambiloto leaves in some dosevariation degree is significantly influential to repair the microanatomicstructure of liver and to decrease the serum GPT level was 37,8 mg/Kg BW.
关键词：diazinon; microanatomic structure of liver; serum GPT;sambiloto; mice.