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标题：Efek Teratogenik Ekstrak Buah Mahkota Dewa ( Phaleria macrocarpa ) pada Tikus Putih ( Rattus norvegicus ) Galur Winstar
本地全文：下载
作者：NURUL WIDYASTUTI ; TETRI WIDIYANI ; SHANTI LISTYAWATI 等
期刊名称：Bioteknologi
印刷版ISSN：0216-6887
出版年度：2006
卷号：3
期号：2
页码：56-62
DOI：10.13057/biotek/c030204
出版社：UNS Solo
摘要：Earlier experiments have established that Phaleria macrocarpa containalkaloids, flavonoids, and saponins. The aim of the research was to find outeffect of giving Phaleria macrocarpa fruit extract orally on growth anddevelopment of rat (Rattus norvegicus L.) fetus during organogenesisperiod and teratogenic dosage. The Complete Randomized Design (CRD)with five treatments group, and each group use five repetitions were usedin this study. Phaleria macrocarpa fruit extract was disolved in aquadestand administrated orally on 7th-17th day of pregnancy. The group treatedwith fruit extract of Phaleria macrocarpa dosage 0; 0.008; 0.017; 0.025; and0.033 g/200 g BW. At 18th day of pregnancy, rats were sacrificed andcaesarian section to remove the fetuses from uterine. Observation onfetuses include: number of living fetus and intrauterine mortality, bodyweight and length, morphological malformation, structure of skeletal andossification result. The quantitative data was analysed by analysis ofvariance and continued with DMRT (Duncan Multiple Range Test).Qualitative data was analysed descriptively. The result of the researchshowed that Phaleria macrocarpa fruit extract dosage 0.008 g/200 g BW to0.033 g/200 g BW caused decrease percentage of living fetuses, increasepercentage of intrauterine mortality, morphological malformation such ashemoraghe, kinkey and ossification disturbance. Dosage of 0.033 g/200 gBW caused micromelia
关键词：Phaleria macrocarpa; teratogenic; Rattus norvegicus;morphological-malformation