文章基本信息

标题：Mycosphere Essays 7: Ganoderma lucidum - are the beneficial anti-cancer properties substantiated?
本地全文：下载
作者：Hapuarachchi KK ; Wen TC ; Jeewon R 等
期刊名称：Mycosphere
印刷版ISSN：2077-7000
电子版ISSN：2077-7019
出版年度：2016
卷号：7
期号：3
页码：305-332
出版社：Mushroom Research Foundation
摘要：Ganoderma lucidum is a popular medicinal mushroom that has been used particularly in China, Japan and Korea for millennia to improve longevity and health. Research on various metabolic activities of G. lucidum have been performed in both in vitro and in vivo studies. There are a vast number of publications that show the abundance and variety of biological actions triggered by the primary metabolites of G. lucidum such as polysaccharides, proteins and triterpenes. However, it is debatable whether G. lucidum is a food supplement for health maintenance or is a therapeutic "drug" for medical purposes. There has been no report of human trials using G. lucidum as a direct control agent for cancers, however, some evidence showing the usage of G. lucidum as potential supplements for cancer patients and a small number of preclinical trials have suggested that it carries promising anti-cancer and immunomodulatory properties. In this review, the beneficial anti-cancer properties of G. lucidum , the evidence for medicinal uses and secondary metabolites, and the effects on human cancer are discussed. G. lucidum and related products can be used as a therapeutic drug, but more direct scientific evidence should be made available in the future. The efficiency of G. lucidum in clinical treatments can be proven by systematic translational research programs using, only standardized preclinically evaluated and biologically active G. lucidum extracts in alternative treatments. Hence, studies on G. lucidum should focus on improving methods and further clinical research on human subjects should be performed with more scientific reproducibility. Furthermore research should target pharmacologically active constituents of G. lucidum that contribute to positive immune responses, as well as the mode of action of G. lucidum at the molecular level at target organs
关键词：Anti-cancer activity – clinical evidence – Ganoderma lucidum – Lingzhi