The development of bacterial resistance to available antibiotics and increasing incidence of multi resistant bacterial infections in hospitals and in the community has necessitated the search for new antibacterial agents to treat the bacterial infection. Thiazoles and their derivatives form a part of Vitamin B₁ and coenzyme carboxylase. They represent a very interesting class of compounds because of their wide applications as antimicrobial, anti-inflammatory, anti-degenerative and anti-HIV activities. In the light of the above we have synthesized some new noble Schiff’s Bases and their G-6 metal carbonyl derivatives. Schiff’s bases viz. N-[(E)-phenylmethylidene](naptho[1,2-d][1,3]thiazol-2-amine (SB¹), N-[(E)-(3-methoxyphenyl)methylidene](naptho[1,2-d][1,3]thiazol-2-amine) (SB²) react with G-6 metal hexacarbonyls in benzene to give monosubstituted derivatives while N-[(E)-phenylmethylidene] (naptho[1,2-d][1,3]thiazol-2-ylimino)methyl]phenol (SB³), 2-methoxy-6-[(E)-(naptho[1,2-d][1,3]thiazol-2-ylimino)methyl]phenol (SB⁴) and N-[(E)-furan-2-ylmethylidine] (naptho[1,2-d][1,3]thiazol-2-amine (SB⁵) react with G-6 metal hexacarbonyls in benzene to give disubstituted derivatives.