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标题：To Study the Formulation of Niosome of Ofloxacin and Its Evaluation for Efficacy of Anti-Microbial Activity
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作者：Alok Kumar Srivastav ; Priyanka Das
期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2014
卷号：3
期号：12
页码：17958
DOI：10.15680/IJIRSET.2014.0312028
出版社：S&S Publications
摘要：Nanotechnology has offered enormous improvement in field of therapeutics by means of designing of nano-carriers that can cross biological barriers and are able to target cellular reservoirs. The aim of the present investigation was to formulate and evaluate Nioso mes, a synthetic microscopic non-ionic surfactant vesicles formed on the admixture of a non-io nic surfactant, cholesterol and phosphate with subsequent hydration in aqueous media. The delivery of drugs b y "vesicular drug delivery system" such as niosomes provides several important advantages over conventional drug therapy. Ofloxacin was selected as a suitable drug for the present study because it is a potent second- generatio n fluoroquinolone active against a broad range of gram positive and gram-negative aerobic and anaerobic bacteria. In the present investigation three formulations of Niosomal drug delivery system of ofloxacin with non ionic surfactant, span 60, in various proportions were prepared and evaluated for Morphological characterization, Encapsulation efficiency, In-vitro drug release stud y. The Ofloxacin nioso mes were prepared by lipid film hydration method. The prepared ofloxacin niosomes showed a vesicle size o f 100-300 nm, the entrapment efficiency was 78.4%. The partition coefficient value of ofloxacin was found to be 0.5.
关键词：Ofloxacin; In-Vitro Release; Ether Injection Method; Entrapment Efficiency; Anti-Microbial Activity.