文章基本信息

标题：Green Synthesis of AgNP'S Using Alternanthera Sessilis Leaf Extract [A Natural Source for Ocular Therapy]
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作者：D Sarvamangala ; Kantipriya Kondala ; U S N Murthy 等
期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2014
卷号：3
期号：7
页码：15000
出版社：S&S Publications
摘要：The present day drug market is almost inundated with a plethora of eye drops and eye ointments to answerprescriptions for curing ocular diseases. A path breaking and innovative thinking is towards employing silver nanoparticles(AgNP’S) effectively and advantageously for sustained drug delivery system, in the prophylactic as well as curativetreatment of ophthalmic indispositions. In this present work, silver nanoparticles obtained through leaf extract ofAlternanthera sessilis (A.sessilis) presented a size of 3 to 50 nm and were round in shape. Particles thus obtained weresubjected to various series of tests viz. UV-Visible Absorption Spectroscopy (UV-Vis), X-Ray Diffraction (XRD),Scanning Electron Microscope (SEM), Energy Dispersive Spectroscope (EDS), Particle Size Analysis (PSA) andTransmission Electron Microscope (TEM) analysis. It is observed that the synchronous action of AgNP’S assuresprevention as well as eradication of ocular pathogens bereft of any side effect and identified the synergetic activity of silvernanoparticles against ocular pathogens. Besides, drugs developed by using silver nanoparticles, have specific biologicaltargets such as replicative, synthetic or metabolic enzymes which are unique to disease causing microbes and can be safelyintroduced into living tissues. Plentiful evidence is available to assert that plenitude of protection against ocular pathogensis provided by AgNP’S, adequately safeguarding intraocular efficacy. The rationale behind the application of silvernanoparticles (AgNP’S) against eye pathogens is – it is cost effective and eco-friendly. Research work on silvernanoparticles against eye pathogens will provide an answer to prevent devastating sight – threatening pathogeniccomplications in the eye.
关键词：Alternanthera sessilis; Ocular diseases; Silver nanoparticles; synergetic activity; Transmission Electron;Microscope.