文章基本信息

标题：Synthesis and characterization of chemically modified collagen based nanobiocomposite containing silver nanorods incorporated with ciprofloxacin
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作者：S. Sekar ; R. Manikandan ; A. Mandal 等
期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2014
卷号：3
期号：2
页码：9618
出版社：S&S Publications
摘要：Recently development of nanobiocomposites (NBC) from biowastes, which has potential biomedicalapplications has gained momentum. Extraction of collagen for biomedical applications from biowastes such as fishscales has received much attention. The present study aims at designing a biocompatible collagen based NBCimpregnated with silver nanorods (AgNRs) and coupled with ciprofloxacin to make it suitable for biomedical purposes.Collagen coated AgNRs were graft co-polymerized with a biocompatible polymer, glycidyl methacrylate (GMA), andcoupled with an antibiotic, ciprofloxacin (C-Ag-G-D). Infrared spectroscopy studies confirmed the grafting of GMA onC while SEM images showed coating of collagen on silver nanorods. DSC and TGA results indicate higherdenaturation temperature with improved thermal stability for the NBC. Antimicrobial studies using E.Coli have shownenhanced antibacterial effect for the NBC. Thus, C-Ag-G-D nanobiocomposite with improved thermal stability andantibacterial activity might be a suitable candidate for biomedical applications.
关键词：Fish scales; Collagen; Silver nanorods; Nanobiocomposites; Ciprofloxacin