文章基本信息

标题：Higher diversity in fungal species discriminates children with type 1 diabetes mellitus from healthy control
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作者：Beata Kowalewska ; Katarzyna Zorena ; Małgorzata Szmigiero-Kawko 等
期刊名称：Patient Preference and Adherence
印刷版ISSN：1177-889X
电子版ISSN：1177-889X
出版年度：2016
卷号：10
页码：591-599
DOI：10.2147/PPA.S97852
出版社：Dove Medical Press Ltd
摘要：Objective: To conduct qualitative and quantitative assessment of yeast-like fungi in the feces of children and adolescents with type 1 diabetes mellitus (T1DM) with respect to their metabolic control and duration of the disease. Materials and methods: The studied materials included samples of fresh feces collected from 53 children and adolescents with T1DM. Control group included 30 age- and sex-matched healthy individuals. Medical history was taken and physical examination was conducted in the two study arms. Prevalence of the yeast-like fungi in the feces was determined as well as their amounts, species diversity, drug susceptibility, and enzymatic activity. Results: The yeast-like fungi were found in the samples of feces from 75.4% of T1DM patients and 70% controls. In the group of T1DM patients, no correlation was found between age (Rs=0.253, P =0.068), duration of diabetes (Rs=−0.038, P =0.787), or body mass index (Rs=0.150, P =0.432) and the amount of the yeast-like fungi isolated in the feces. Moreover, no correlation was seen between the amount of the yeast-like fungi and glycated hemoglobin (Rs=0.0324, P =0.823), systolic blood pressure (Rs=0.102, P=0.483), or diastolic blood pressure (Rs=0.271, P =0.345). Conclusion: Our research has shown that children and adolescents with T1DM show higher species diversity of the yeast-like fungi, with Candida albicans being significantly less prevalent versus control subjects. Moreover, fungal species in patients with T1DM turn out to be more resistant to antifungal treatment.
关键词：children; diabetes mellitus type 1; yeast-like fungi; drug susceptibility; metabolic control; duration of the disease