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标题：Identification of Cyclopropylacetyl-( R )-carnitine, a Unique Chemical Marker of the Fatally Toxic Mushroom Russula subnigricans
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作者：Masanori Matsuura ; Suguru Kato ; Yoko Saikawa 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2016
卷号：64
期号：6
页码：602-608
DOI：10.1248/cpb.c15-01033
出版社：The Pharmaceutical Society of Japan
摘要：A toxic mushroom, Russula subnigricans , causes fatal poisoning by mistaken ingestion. In spite of the potent bioactivity, the responsible toxin had not been identified for about 50 years since its first documentation. Recently, we isolated an unstable toxin and determined the structure. The slow elucidation was partly due to the instability of the toxin and also due to misidentification of R. subnigricans for similar mushrooms. To discriminate genuine Russula subnigricans from similar unidentified Russula species, we searched for a unique chemical marker contained in the mushroom. Cyclopropylacetyl-( R )-carnitine specific to R. subnigricans was identified as a novel compound whose ¹H-NMR signals appearing in the upfield region were easily recognizable among the complicated signals of the crude extract.