文章基本信息

标题：Locomotor-Reducing Activity of Sesquiterpenes Related to Zingiber zerumbet Essential Oil and Hexahydrozerumbone Derivatives
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作者：Kakuyou Ogawa ; Hironobu Yabe ; Takashi Kitayama 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2016
卷号：39
期号：6
页码：1077-1080
DOI：10.1248/bpb.b16-00141
出版社：The Pharmaceutical Society of Japan
摘要：Zerumbone derivatives 1 – 4 are 11-membered cyclic compounds synthesised from a sesquiterpene zerumbone obtained from the rhizomes of Zingiber zerumbet SMITH (Zingiberaceae). In this study, we investigated the locomotor-reducing effects of hexahydrozerumbone derivatives 1 – 3 and zerumbol 4 , and those of β-caryophyllene 5 and caryophyllene oxide 6 , which are present in Z. zerumbet essential oil. The absence of the double bond at C6 weakened the locomotor-reducing effects. β-Caryophyllene 5 and caryophyllene oxide 6 showed locomotor-reducing effects in mice at 4.5×10⁻³ mg/cage. Moreover, locomotor activity increased significantly at 0.45 mg/cage of caryophyllene oxide 6 .