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标题：Synthesis, Spectral, Anti-Corrosion, Anti-Microbial Studies Of Some New Heterocyclic Derivatives Incorporating Piperidone-4 Moiety
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作者：Kholoud Fahed Hamak
期刊名称：Journal of Current Research in Science
印刷版ISSN：2322-5009
出版年度：2013
卷号：1
期号：1
页码：40-49
出版社：Islamic press
摘要：The reaction of 3-Isobutyl-2,6-di(thienyl-2) piperidin-4-one with thiosemicarbazide, Phenacylbromide, 4-aminoantipyrine, N-aminoquinoline-2-one, thiocarbohydrazide afforded. 3-Isobutyl-2,6-di(thienyl-2) piperidin-4-one, thiosemicarbazone 2, 2-(3-isobutyl-2,6-di(thienyl-2)piperidin-4-ylidene)hydrazono)-4-phenyl-2, 3-dihydrothi azole 4, 4-((3-isobutyl-2,6-di(thienyl-2)piperidin-4-ylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one5,1-((3-isobutyl-2,6-di(thienyl-2)piperidin-4-ylidene)amino)quinolin-2(1H)-one8,3-Isobutyl-2,6-di(thienyl-2) piperidin-4-thiocarbohydraz one 9, The resulted compounds were reacted with various nucleophiles in order to obtain new heterocyclic derivatives. Chemical structures of all products were confirmed by IR, MS, 1H-, 13C-NMR spectral data. All synthesized compounds were in vitro tested against a standard strain of pathogenic microorganism inclosing Gram +ve bacteria (Staphylococcus aureus), Gram-ve bacteria (Escherichia coli). Compounds 2,3 exerted strong antibacterial activity against (E.coli, Staph. aureus ) while compounds (1,4-10)exerted good activity against (Staphylococcus aureus) more than (E.coli). Ten synthesized piperidone-4 derivatives were tested to determine their ability to inhibit corrosion of mild steel in 1 mol.L-1 H2SO4and measured by polarization measurements the. All ten compounds show good inhibition efficiency in the following order: 2>9>6>7>8>3>4>1>10>5 polarization measurements indicated that these compounds behave as a mixed mode inhibitor ,the studies revealed that the imine nitrogen , the piperidin moiety and the phenyl ring assist largely in corrosion control
关键词：2;6-diarylpiperidin-4-one; Schiff bases; thiosemicarbazone; 2-thioxo-imidazolidin-4-one; polarization; antipyrine; antimicrobial activity.