Pheochromocytoma remains one of the great challenges to anesthesiologists during anesthesia and postoperative period. Virtually all anesthetic agents and techniques have been used with success but associated with a high rate of transient intraoperative arrhythmia and hypertension. We now report one case who was given thoracic epidural block and neuroleptic anesthesia for resection of right adrenal and presacral pheochromocytoma. Blood pressure and heart rate were stable during induction, tumor manipulation and postoperative intensive care unit with out the use of vasodilating or antiarrhythmic druas. While this report describes only one encouraging case, the potential advantages of thoracic epidural & general anesthesia in pheochromocytoma appear to warrant the further trial.