文章基本信息

标题：Effect of 0.05% Cyclosporine A on the Ocular Surface after Photorefractive Keratectomy
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作者：Kim, Yong Il ; Koo, Sung Hyun ; Ha, Sang Won 等
期刊名称：Journal of the Korean Ophthalmological Society
印刷版ISSN：0378-6471
出版年度：2016
卷号：57
期号：5
页码：710-717
DOI：10.3341/jkos.2016.57.5.710
语种：Korean
出版社：The Korean Ophthalmological Society
摘要：Purpose
To evaluate the effect of 0.05% cyclosporine A on the ocular surface after photorefractive keratectomy (PRK).
Methods
This retrospective study included 50 patients who underwent PRK. Patients were divided into two groups: 25 patients in group I were treated with topical 0.05% cyclosporine A with conventional medication, and 25 patients in group II were treated with conventional medication. Visual acuity (VA), tear break-up time (BUT), fluorescein staining score (F-stain), Schirmer I test, and ocular surface disease index (OSDI) were evaluated before surgery and 2 weeks, 1 month, 2 months, and 3 months after surgery.
Results
F-stain was significantly lower in group I than in group II at 2 weeks and 1 month ( p < 0.05). There was no significant difference in uncorrected VA, BUT, Schirmer I test, or OSDI between the groups. However, group I showed a more effective pattern in dry eye.
Conclusions
Combination treatment with 0.05% cyclosporine A was helpful for early ocular surface stability in patients with dry eye after PRK.
关键词：Cyclosporine A; Dry Eye; Ocular surface stability; Photorefractive keratectomy; Refractive surgery