文章基本信息

标题：Does Metabolically Healthy Obesity Exist?
本地全文：下载
作者：Araceli Muñoz-Garach ; Isabel Cornejo-Pareja
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2016
卷号：8
期号：6
页码：320
DOI：10.3390/nu8060320
语种：English
出版社：MDPI Publishing
摘要：The relationship between obesity and other metabolic diseases have been deeply studied. However, there are clinical inconsistencies, exceptions to the paradigm of “more fat means more metabolic disease”, and the subjects in this condition are referred to as metabolically healthy obese (MHO).They have long-standing obesity and morbid obesity but can be considered healthy despite their high degree of obesity. We describe the variable definitions of MHO, the underlying mechanisms that can explain the existence of this phenotype caused by greater adipose tissue inflammation or the different capacity for adipose tissue expansion and functionality apart from other unknown mechanisms. We analyze whether these subjects improve after an intervention (traditional lifestyle recommendations or bariatric surgery) or if they stay healthy as the years pass. MHO is common among the obese population and constitutes a unique subset of characteristics that reduce metabolic and cardiovascular risk factors despite the presence of excessive fat mass. The protective factors that grant a healthier profile to individuals with MHO are being elucidated.
关键词：metabolically healthy obesity; metabolic syndrome; adipose tissue; inflammation metabolically healthy obesity ; metabolic syndrome ; adipose tissue ; inflammation