文章基本信息

标题：Salvianolic Acid B Inhibits Aβ Generation by Modulating BACE1 Activity in SH-SY5Y-APPsw Cells
本地全文：下载
作者：Ying Tang
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2016
卷号：8
期号：6
页码：333
DOI：10.3390/nu8060333
语种：English
出版社：MDPI Publishing
摘要：Alzheimer’s disease (AD) is a neurodegenerative disease in humans. The accumulation of amyloid-β (Aβ) plays a critical role in the pathogenesis of AD. Previous studies indicated that Salvianolic acid B (SalB) could ameliorate Aβ-induced memory impairment. However, whether SalB could influence the generation of Aβ is unclear. Here, we show that SalB (25, 50, or 100 µM) reduces the generation of Aβ40 and Aβ42 in culture media by decreasing the protein expressions of BACE1 and sAPPβ in SH-SY5Y-APPsw cells. Meanwhile, SalB increases the levels of ADAM10 and sAPPα in the cells. However, SalB has no impact on the protein expressions of APP and PS1. Moreover, SalB attenuates oxidative stress and inhibits the activity of GSK3β, which might be related to the suppression of BACE1 expression and amyloidogenesis. Our study suggests that SalB is a promising therapeutic agent for AD by targeting Aβ generation.
关键词：Alzheimer’s disease; Salvianolic acid B; Aβ generation; BACE1; oxidative stress; GSK3β Alzheimer’s disease ; Salvianolic acid B ; Aβ generation ; BACE1 ; oxidative stress ; GSK3β