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标题：Epidemiological characteristics of human prion diseases
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作者：Cao Chen ; Xiao-Ping Dong
期刊名称：Infectious Diseases of Poverty
印刷版ISSN：2049-9957
出版年度：2016
卷号：5
期号：1
页码：47
DOI：10.1186/s40249-016-0143-8
语种：English
出版社：BioMed Central
摘要：Human prion diseases are a group of transmissible, progressive, and invariably fatal neurodegenerative disorders, which include Kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome, and fatal familial insomnia. Human prion diseases affect approximately 1–2 persons per million worldwide annually, occurring in sporadic, inherited, and acquired forms. These diseases have attracted both scientific and public attention not only because of their mysterious pathogen, but also due to their considerable threat to public health since the emergence of the variant CJD. There are still no specific therapeutic and prophylactic interventions available for prion diseases, thus active surveillance of human prion diseases is critical for disease control and prevention. Since 1993, CJD surveillance systems have been established in many countries and regions, and several long-term multinational cooperative projects have been conducted. In this paper, the epidemiological characteristics of various human prion diseases and the active surveillance systems pertaining to them in different countries and regions are summarized and reviewed.
关键词：Prion disease ; Epidemiology ; Creutzfeldt-Jakob disease ; Surveillance