文章基本信息

标题：New Isolinariins C, D and E, Flavonoid Glycosides from Linaria japonica
本地全文：下载
作者：Retno Widyowati ; Sachiko Sugimoto ; Yoshi Yamano 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2016
卷号：64
期号：5
页码：517-521
DOI：10.1248/cpb.c16-00073
出版社：The Pharmaceutical Society of Japan
摘要：Three new flavonoid glycosides named isolinariins C, D and E ( 1 – 3 ), two known flavonoid glycosides ( 4 , 5 ) and three known flavonoids ( 6 – 8 ) were isolated from the whole plant of Linaria japonica . The structures of these compounds were determined mainly by spectroscopic analyses. The bioactivities of these isolated compounds were evaluated for their inhibitory activities against human cell line A549, collagenase, and advanced glycation end product (AGE) formation. Among the isolated compounds, isolinariins C, D and E ( 1 , 2 and 3 ) showed inhibition toward AGE formation (IC₅₀ values of 34.8, 35.0 and 19.5 µM, respectively). And linariin ( 4 ), pectolinarin ( 5 ) and luteolin ( 8 ) were found to be active against collagenase with IC₅₀ values of 79.4, 78.6 and 40.5 µM, respectively, without significant cytotoxicity at these concentrations.