摘要:Nine neo-clerodane diterpenoids and a mixture of C-16 epimers - scutegalerins C and D, isolated from Scutellaria galericulata (Labiatae), were tested for insect antifeedant activity against Leptinotarsa decemlineata (Say) larvae in choice feeding assays. Treatment of potato leaf disks with small amounts of the natural products (1000, 100, 10 ppm) demonstrated a significant antifeedant activity. Results were compared with one of the used in feeding assays compounds - 14,15-dihydrojodrellin T, which is known as a very powerful feeding suppressor and deterrent against insect pests. Activity was established by calculating the feeding ratio (FR) between the consumed areas of treated disks (CTD) and control disks (CCD). To obtain comparison results was established a FR50 determined as the FR at a CCD of 50% was established. Some of the compounds exhibited activity at dose 10 ppm (0.33 μg/cm2). The purpose of this study was to define the structural features of the clerodanes and to determine their antifeedant activity