文章基本信息

标题：IL-17 and IL-22 genetic polymorphisms in HBV vaccine non- and low-responders among healthcare workers
本地全文：下载
作者：Zohreh Borzooy ; Adrian Streinu-Cercel ; Abbass Mirshafiey 等
期刊名称：Germs
印刷版ISSN：2248-2997
出版年度：2013
卷号：3
期号：4
页码：14-20
DOI：10.11599/germs.2016.1084
出版社：European HIV/AIDS and Infectious Diseases Academy
摘要：Background Healthcare workers constitute a population at high risk for HBV infection. Efficient vaccination options are available; however, the individual response to HBV vaccination may vary widely between subjects, potentially due to cytokine profiles and genetic variations. In the present study, we investigated the relationship between IL-17 and IL-22 gene polymorphisms versus non- and low-responsiveness to HBV vaccination in healthcare workers.Methods We selected the following IL-17 and IL-22 polymorphisms: rs4711998 (A/G) from IL-17 and rs2227501 (A/T), rs2227503 (A/G), rs1026786 (A/G) from IL-22 sequences genes. These were determined by polymerase chain reaction restriction fragment length polymorphisms. Results The IL-17 rs4711998 GG genotype had a significantly lower frequency in non-responders compared to low-responders (p=0.025). However, we did not identify a relationship between IL-22 rs1026780, rs2227501 and rs2227503 genotypes and the anti-HBs response following HBV vaccination.Conclusion These data suggest that genetic variation in rs4711998 polymorphisms in the IL-17 cytokine may influence vaccine-induced immune responses to HBV vaccine in healthcare workers.
关键词：HBV vaccine; healthcare workers; IL-17; IL-22; gene polymorphisms