文章基本信息

标题：Protein Intake and Muscle Health in Old Age: From Biological Plausibility to Clinical Evidence
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作者：Francesco Landi ; Riccardo Calvani
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2016
卷号：8
期号：5
页码：295
DOI：10.3390/nu8050295
语种：English
出版社：MDPI Publishing
摘要：The provision of sufficient amounts of dietary proteins is central to muscle health as it ensures the supply of essential amino acids and stimulates protein synthesis. Older persons, in particular, are at high risk of insufficient protein ingestion. Furthermore, the current recommended dietary allowance for protein (0.8 g/kg/day) might be inadequate for maintaining muscle health in older adults, probably as a consequence of “anabolic resistance” in aged muscle. Older individuals therefore need to ingest a greater quantity of protein to maintain muscle function. The quality of protein ingested is also essential to promoting muscle health. Given the role of leucine as the master dietary regulator of muscle protein turnover, the ingestion of protein sources enriched with this essential amino acid, or its metabolite β-hydroxy β-methylbutyrate, is thought to offer the greatest benefit in terms of preservation of muscle mass and function in old age.
关键词：sarcopenia; frailty; malnutrition; leucine; anorexia; supplementation; amino acid sarcopenia ; frailty ; malnutrition ; leucine ; anorexia ; supplementation ; amino acid