文章基本信息

标题：Role of Vitamin D in Cognitive Function in Chronic Kidney Disease
本地全文：下载
作者：Zhen Cheng
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2016
卷号：8
期号：5
页码：291
DOI：10.3390/nu8050291
语种：English
出版社：MDPI Publishing
摘要：Both vitamin D deficiency and cognitive impairment are common in patients with chronic kidney disease (CKD). Vitamin D exerts neuroprotective and regulatory roles in the central nervous system. Hypovitaminosis D has been associated with muscle weakness and bone loss, cardiovascular diseases (hypertension, diabetes and hyperlipidemia), inflammation, oxidative stress, immune suppression and neurocognitive impairment. The combination of hypovitaminosis D and CKD can be even more debilitating, as cognitive impairment can develop and progress through vitamin D-associated and CKD-dependent/independent processes, leading to significant morbidity and mortality. Although an increasingly recognized comorbidity in CKD, cognitive impairment remains underdiagnosed and often undermanaged. Given the association of cognitive decline and hypovitaminosis D and their deleterious effects in CKD patients, determination of vitamin D status and when appropriate, supplementation, in conjunction with neuropsychological screening, should be considered integral to the clinical care of the CKD population.
关键词：vitamin D; hypovitaminosis D; cognitive impairment; chronic kidney disease; dialysis vitamin D ; hypovitaminosis D ; cognitive impairment ; chronic kidney disease ; dialysis