文章基本信息

标题：DNA Vaccines Approach: From Concepts to Applications
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作者：Vanessa Bastos Pereira ; Meritxell Zurita-Turk ; Tessália Diniz Luerce Saraiva 等
期刊名称：World Journal of Vaccines
印刷版ISSN：2160-5815
电子版ISSN：2160-5823
出版年度：2014
卷号：04
期号：02
页码：50-71
DOI：10.4236/wjv.2014.42008
语种：English
出版社：Scientific Research Publishing
摘要：DNA vaccines are the third generation vaccines based on purified plasmid preparations containing transgenes that encode antigenic/therapeutic proteins or peptides capable of triggering an immune response against a wide range of diseases. This vaccine platform presents several attributes that confer distinct advantages over other vaccine technologies in terms of safety, ease of fabrication and stability. Many aspects, such as antigen expression and especially vector design, are under study because of their great influence on immunogenicity and efficacy of DNA vaccines. In this regard, with the attempt of improving the efficiency of DNA vaccines, co-expression of stimulatory sequences and diverse vector delivery systems are being optimized. With this in mind, this review aims to giving a conceptual approach of DNA vaccines, explaining their mechanisms of action and listing the already licensed veterinary DNA vaccines presented in the market.
关键词：DNA Vaccines; Vector Design; Delivery Systems; Approved DNA Vaccines; Bacterial Delivery