文章基本信息

标题：Efficacy of Ascorbic Acid (Vitamin C) and/N-Acetylcysteine (NAC) Supplementation on Nutritional and Antioxidant Status of Male Chronic Obstructive Pulmonary Disease (COPD) Patients
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作者：Elham PIRABBASI ; Suzana SHAHAR ; Zahara Abdul MANAF 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2016
卷号：62
期号：1
页码：54-61
DOI：10.3177/jnsv.62.54
出版社：Center for Academic Publications Japan
摘要：Antioxidant therapy has a potential to be introduced as therapeutic modality for chronic obstructive pulmonary disease (COPD) patients. This study aimed to determine the effect of antioxidant supplementation [ascorbic acid and N-Acetylcysteine (NAC)] on nutritional and antioxidant status in male COPD patients. A parallel and single blind randomised controlled clinical trial (RCT) was conducted at two medical centers in Kuala Lumpur, Malaysia. Seventy-nine subjects were recruited and randomly divided into four trial arms (i.e., NAC, vitamin C, NAC+vitamin C and control groups) for six mo. The primary outcome was changes in body mass index by estimating power of 90% and significance level of p <0.05. Repeated Measure ANOVA showed that there was a significant interaction effect on BMI ( p =0.046) and carbohydrate intake ( p =0.030), especially in the NAC group. Plasma glutathione (GSH) increased significantly in all intervention groups, especially in vitamin C ( p =0.005). A single supplementation of NAC or vitamin C improved nutritional and antioxidant status of subjects.
关键词：dietary supplements;malnutrition;nutritional support;chronic obstructive pulmonary disease;antioxidants