文章基本信息

标题：Tumor Necrosis Factor Alpha In Preeclampsia
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作者：Fozia A Patigaroo ; Anwar H Siddiqui ; Rajiv Gulati 等
期刊名称：International Journal of Basic & Applied Physiology
印刷版ISSN：2320-172X
出版年度：2013
期号：1
页码：224-228
语种：English
出版社：Society of Basic & Applied Physiology
摘要：Pre-eclampsia is one of the most frequent complications of pregnancy, however, little is known about its aetiology. Insufficient adaptation of the decidual and intramyometrial portions of the spiral arterioles in preeclampsia results in reduced utero-placental blood flow, leading to local placental hypoxia. Pre-eclampsia is pregnancy-induced hypertension (PIH) of unknown etiology. Pre-eclampsia can be quite serious as it can lead to various complications both for the mother and the baby. In fact, pre-eclampsia and eclampsia, severe forms of PIH, are the leading cause of infant and maternal death in India. Hypertension complicates an estimated 6-8% of all pregnancies. Significant risk factors identified in univariate analysis included pre pregnancy body mass index (BMI > 25) (OR = 11.27), history of chronic hypertension (OR = 8.65), history of diabetes (OR = 11.0), history of renal disease (OR = 7.98), family history of hypertension (OR = 5.4), history of pre-eclampsia in earlier pregnancy (OR = 9.63), and multiple pregnancy (OR = 4.85). Cytokines are major contributors in pathogenesis of pre eclampsia. Several studies confirm a significant increase (p