文章基本信息

标题：Cleavage Furrow Formation for Avascular Tumor Growth based on Finite Element Modeling
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作者：Changyu Liu ; Dapeng Li ; Bin Lu 等
期刊名称：International Journal of Multimedia and Ubiquitous Engineering
印刷版ISSN：1975-0080
出版年度：2015
卷号：10
期号：3
页码：219-230
DOI：10.14257/ijmue.2015.10.3.21
出版社：SERSC
摘要：A number of studies have shown that the prevention and cure of malignant tumors may become much easier if growth mechanisms, such as the role of cleavage furrow formation in tumor cell division, could be discovered and understood in the earlier avascular phase. Although it is well known that metazoan mitotic spindle which is one of the most important substances during the cytokinesis of a cell division determines the position of the cleavage furrow formation, we are still on the verge of solving the puzzle of what molecules and how they control the formation of the cleavage furrow. In this paper, we propose a cleavage furrow formation approach based on finite element method, which combines nodes selection, mesh partition and matrix assembly in a total energy equation, for modeling the mechanisms of avascular tumor growth. We also perform several experiments. Results show that, by using our proposed approach for the avascular tumor growth, the positions of cleavage furrows are decided not only chemically but also physically and tumor cells are not symmetric, which demonstrates the effectiveness of our proposed approach.
关键词：cleavage furrow formation; cell division; finite element; avascular tumor growth