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标题：Formulation and Evaluation of Enteric Coated Sustain Release Tablets of Lansoprazole in a β-Cyclodextrin Complex to Improve the Photostability
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作者：Madusudhan RaoYamsani ; Shravan Kumar Y ; Architha S 等
期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2015
卷号：4
期号：11
页码：11630
DOI：10.15680/IJIRSET.2015.0411140
出版社：S&S Publications
摘要：Enteric coated sustain release Lansoprazoletablets which are proton pump inhibitors i n action, are widely used in the treatment of gastric ulcers. The aim of the present study is to improve photostabilityo f Lansoprazole. Enteric Coated sustain release tablets of Lansoprazolewere formulates by using enteric polymers like Kollicoat MAE 30DP, and Eudragit L 100. Primary characterization of the drug was done by performing the melting point, identification test by Fourier Transform Infrared Spectroscopy, solubility and assay. To understand the compatibility of the drug with excipients, drug -excipient studies were carried out using Infrared spectroscopy. Using complexation technique different ratios of the drug were complexed with cyclodextrin to improve photostability. The stability test results indicated that the inclusion complex was more stable than raw Lansoprazole in the light. It was observed that inclusion complex of Lansoprazole showed increased the solubility by about 4.5 times. There were no significant differences between 30 min, 6 h and 24 h for either raw material or inclusion complex. Among the four polymers chitosan, xanthum gum, locust bean gum, and guar gum as polymers, chitosan was chosen for further coating process. Physico-chemical and in-vitro drug release studies were performed to all the formulations. F4c formulation was fo und to be best formulation which showed better resistance in 0.1N HCL, sustained well and with in-vitro release of97.83± 0.39% release in 12hrs.
关键词：Complexation; FTIR; Beta cyclodextrin; Chitosan; Gastric ulcers; Kollicoat; Lansoprazole; Photostability