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标题：Assessment of multimarker responses in Perna perna , Mytilus galloprovincialis and Donax trunculus bivalves exposed to malathion and 2,4-dichlorophenoxyacetic acid pesticides
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作者：Banaoui A. ; El Hamidi F. ; Kaaya A. 等
期刊名称：Journal of Materials and Environmental Science
印刷版ISSN：2028-2508
出版年度：2015
卷号：6
期号：6
页码：1678-1683
出版社：University of Mohammed Premier Oujda
摘要：The early biological effects of pesticides was assessed in three species of bivalves: Perna perna, Mytilus galloprovincialis and Donax trunculus, exposed to 500 μ g/L of malathion Mal (organophosphorous pesticide; OP) and 2,4- Dichlorophenoxyacetic acid 2,4-D (organochlorinated pesticide; OC). The responses of acetylcholinesterase (AChE, biomarker of neurotoxicity), glutathione S-transferase (G ST, biomarker of detoxification) and catalase activities; and malonedialdhyde levels (CAT and MDA; biomarkers of oxidative stress and lipid peroxidation) were characterized. The mortality rate of bivalves was determined as biomarker of general stress. The results revealed critical alterations of the measured sub-cellular parameters. The alterations of the biomarkers responses depend on the pesticide and time of exposure. AChE showed a significant inhibition in all species along the experiment; which could be explained by neurotoxic effect due to the high sensitivity of AChE to pesticides, especially organophosphorous compounds. While, GST activity was significantly increased (P< 0.01) after 24h of exposure to 2,4-D (85 % of induction in P. perna at 48h). CAT activity and lipid peroxydation were induced after 12h of exposure to pesticides indicting a high generation of free oxyradicals. Meanwhile, mortality increased progressively according the exposure time (more than 30%). The multimarker responses used in these exp eriments demonstrated clearly the early biological effects (biochemical dysfunctions) and mortality rate increase of Perna perna, Mytillus galloprovincialis, Donax trunculus exposed to the sub-lethal concentration of malathion and 2,4-dichlorophenoxyacetic acid pesticides.
关键词：Perna perna; Mytillus galloprovincialis; Donax trunculus; multimarker approch; Malathion; 2;4;D.