文章基本信息

标题：GENETIC ANALYSIS OF PATIENTS WITH PRIMARY OPEN ANGLE GLAUCOMA (POAG) IN NORTH INDIAN POPULATION
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作者：Abhishek Dixit ; Diksha Prakash ; Samir Kumar 等
期刊名称：The Journal of Community Health Management
印刷版ISSN：2394-272X
电子版ISSN：2394-2738
出版年度：2015
期号：4
页码：168-178
语种：
出版社：Innovative Publication
摘要：Aim: To investigate the role of the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism in a large cohort of patients with POAG. Methods: genetic analysis of 80 patients of POAG and 80 controls was done for MTHFR 677C>T polymorphism using PCR. Results: The C677T genotype is found to be very significantly associated with POAG) as compared to the controls. There is a significant difference in the frequency of distribution of genotype. The homozygous mutant genotype (TT) is also 1.25% more in cases as compared to controls. Conclusion: There is significant association of MTHFR 677C>T polymorphism with POAG.